is comma and .....necessary? Grammar English help?

which are the differences?

1. Draw the picture using only a red marker or a blue marker.

2. Draw the picture using only a red marker or blue marker.

3. Draw the picture using only a red or a blue marker.

4. Draw the picture using only a red or blue marker.

5. Draw the picture using only a red marker ,or a blue marker.

Any grammar mistakes?

Thank you and explain please thank you very much

thank you